The Universes Influenced by the Fyrox Faction -- the Architects and Archons who all believe in the gift of Freedom. The worlds here tend to be more curious, in nature, as they've typically been directly affected by the War.
The Universes Influenced by the Zegnum Faction -- the Architects and Archons who all believe in the safety of Security. The worlds here tend to be more stable as these Universes typically have been spared from the effects of the War.
Some events are vast enough to touch multiple -- if not every -- Universe at once. These cataclysmic events require all of the Architects to come together to overcome these existential threats.